Titlebook: Cancer and Zebrafish; Mechanisms, Techniqu David M. Langenau Book 2016 The Editor(s) (if applicable) and The Author(s), under exclusive lic

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https://doi.org/10.1007/b102415n developmental programs and disease, and simultaneously provides a platform for the discovery of novel therapeutics. The zebrafish is an advantageous model for in vivo high-throughput small molecule screening due to translational appeal, high fecundity, and a unique set of developmental characteris

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https://doi.org/10.1007/b102415insight into the mechanisms of tumorigenesis and the there are many techniques for analyzing the genomes of these tumors. Here, I present an overview of the available technologies for analyzing tumor genomes in the zebrafish, including array based methods as well as next-generation sequencing techno

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Introducing Geostatistical Methodsn, and studies using model organisms such as zebrafish provide an opportunity to address these important questions. Modifications of histones and DNA comprise the complex epigenome, and these influence chromatin structure, genome stability and gene expression, all of which are fundamental to the cel

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Introducing Geostatistical Methodsrafish model including ex vivo development and large clutch sizes, which enable large-scale genetic and chemical screens. Transparency of the embryo and the creation of adult zebrafish devoid of pigmentation (.) have permitted unprecedented ability to dynamically visualize cancer progression in live

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Introducing Geostatistical Methodse for studying development, immunology, regeneration and cancer biology. In experimental settings, tumor cell engraftment into immunologically competent recipients has greatly increased our understanding of the mechanisms that drive self-renewal, progression and metastasis in vivo. Zebrafish have qu

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