Titlebook: Cancer Therapeutics; Experimental and Cli Beverly A. Teicher Book 1997 Springer Science+Business Media New York 1997 DNA.angiogenesis.cance

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A. V. Karpov,V. I. Zagrebaev,W. Greinerompounds, the aryl- and alkyl-bis(2-chloroethyl)amines, were covered in the previous chapter. Two oxazaphosphorines, cyclophosphamide and ifosfamide (Fig. 1), are the only phosphorylated mustard compounds ordinarily prescribed for cancer treatment today (.). The developmental work that led to their

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J. H. Hamilton,A. V. Ramayya,E. H. Wangfort to discover other antibiotic substances for potential use in the treatment of malignancies. As a result, cancer chemotherapy was altered immeasurably more than 30 years ago by the independent discoveries by Grein (.), Dubost (.), and their colleagues of an anthracycline antibiotic, derived from

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https://doi.org/10.1007/978-3-319-44165-8s can also be coiled in circular DNA. This structure was called supercoiling. This finding was extended to linear DNA by Pettijohn and others (.). It is now known that practically all DNA in vivo is supercoiled (.). Because most of the functions of DNA require untwisting, the importance of the enzym

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