Titlebook: Cancer Stem Cells; Methods and Protocol Gianpaolo Papaccio,Vincenzo Desiderio Book 2018 Springer Science+Business Media LLC 2018 Tumor type

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International Year of Planet Earthdentify genetic determinants of drug resistance versus sensitivity, and to study new stem cell-directed therapies. Here, we describe our standardized procedure for in vitro drug screening on colorectal CSCs, taking irinotecan as an example.

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Studies in the Natural Sciences to conventional radiochemotherapy regiments and increased metastatic potential. Clinically, the aggressive nature of CSCs has been shown to correlate with increased tumor recurrence, metastatic spread, and overall poor patient outcome across multiple cancer subtypes. Traditionally, isolation of CSC

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Teams: Building, Adaptation and Learningibed the role of ALDH in the identification of cancer stem cells (CSCs), having been shown that stem cells express high levels of ALDH. Here, we present a method called ALDEFLUOR assay used for the identification, evaluation, and isolation of normal, cancer stem and progenitor cells.