Titlebook: Cancer Metabolism; Methods and Protocol Majda Haznadar Book 2019 Springer Science+Business Media, LLC, part of Springer Nature 2019 Human B

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Integrated Analysis of Acetyl-CoA and Histone Modification via Mass Spectrometry to Investigate Met, facilitates the accessibility of DNA for gene transcription. The central metabolite, acetyl-CoA, is a substrate for acetyltransferases, which catalyze protein acetylation. Acetyl-CoA is an essential intermediate in diverse metabolic pathways, and cellular acetyl-CoA levels fluctuate according to e

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Lipidomic Analysis of Cancer Cell and Tumor Tissues,key importance to understand cancer biology. In addition, several mass spectrometry-based profiling as well as imaging studies have indicated that lipid molecules may be useful to augment existing biochemical and histopathological methods for diagnosis, staging, and prognosis of cancer. Therefore, a

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Mass Spectrometry-Based Profiling of Metabolites in Human Biofluids,ain elusive in most types of cancer. In addition, lacunae in our understanding of cancer biology continue to hinder advancement of therapeutic strategies. Metabolic reprogramming has been identified as integral to pathogenesis and progression of the disease. Consequently, analysis of biofluid metabo

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Gas Chromatography-Mass Spectrometry and Analysis of the Serum Metabolomic Profile Through Extractiive analysis and detection of slight differences in metabolite concentrations. Gas chromatography-mass spectrometry (GC-MS) is widely used for characterizing the metabolome. This chapter summarizes the necessary preparatory steps required to profile the metabolome using GC-MS. While this chapter foc

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Metabolite Profiling of Clinical Cancer Biofluid Samples by NMR Spectroscopy,tforms commonly used to study metabolic alterations in biofluid samples is proton nuclear magnetic resonance (.H NMR) spectroscopy. NMR spectroscopy is very specific, quantitative, and highly reproducible. Moreover, sample preparation for NMR experiments is very simple and straightforward, and this

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Assessing Metabolic Dysregulation in Muscle During Cachexia,rticular, skeletal muscle, which represents almost 50% of the total body mass, is strongly affected, and metabolic alterations therein (e.g., insulin resistance and mitochondrial dysfunction) can eventually support tumor growth by facilitating nutrient scavenging by the growing mass. Interestingly,

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