Titlebook: Cancer Immunology; A Translational Medi Nima Rezaei Book 20151st edition Springer-Verlag Berlin Heidelberg 2015 Cancer Immunotherapy.Cancer

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978-3-662-51252-4Springer-Verlag Berlin Heidelberg 2015

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W. Osswald,E. Rodrigues-Pereira is composed of soluble and cellular components, including several cytokines and chemokines, growth factors, enzymes, as well as host cells: endothelial cells, fibroblasts, and leukocytes. Tumor-associated myeloid cells (TAMC) represent the preponderant part of tumor-infiltrating leukocytes; they ar

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https://doi.org/10.1007/978-3-642-71313-2te, where they can recognize the transformed cells. Recognition of tumor cells is mediated by receptors expressed on the surface of innate immune cells, such as NK receptors, CLRs, as well as phagocytosis receptors expressed on APCs. Additionally, factors released from stressed cells at the tumor mi

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W. Osswald,E. Rodrigues-Pereirargent roles in T cell differentiation and effector function. Over the years, the role of B cells in the host immune response to malignancy has been overshadowed by our focus on T cells and remains to be fully defined. While studies on B cells in immune responses have been focused on antigen presenta

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W. Osswald,E. Rodrigues-Pereiranity. However, despite homing into tumor sites, infiltrating T cells seldom control tumor growth and T cell-directed immunotherapy has not been successful. Initially, anergy was implicated in the nonresponsiveness of T cells to tumors. Nevertheless, cancer has been hypothesized to be a chronic disea

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W. Osswald,E. Rodrigues-Pereiraronments appears to be largely true, but an increasing body of evidence suggests that certain types of cancer are formed in inflammatory conditions and tumors produce a number of inflammatory mediators. The tolerogenic nature of the tumor microenvironment is reflected in the presence of a large numb

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https://doi.org/10.1007/978-3-642-71313-2sponses. While certain cytokines that are produced in the tumor microenvironment can function to inhibit tumor growth, others can promote tumor growth and progression. This chapter reviews the roles of pro-tumor cytokines (TGF-β, IL-17, IL-23, IL-35, and IL-10) that have pathogenic significance in c

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https://doi.org/10.1007/978-3-642-71313-2ctions associated with tumor development, they are ideal targets for investigating tumor progression, prognosis, therapy, and susceptibility. In this chapter, the mechanism through which chemokines control the different stages of oncogenesis is described. At first, a detailed description on the role

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