Titlebook: Cancer Immunology; A Translational Medi Nima Rezaei Book 20151st edition Springer-Verlag Berlin Heidelberg 2015 Cancer Immunotherapy.Cancer

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Introduction on Cancer Immunology and Immunotherapy,rn result in significant therapeutic effects in a variety of cancers. Moreover, immunotherapy is being established as a major class of drugs for cancer therapy. This chapter will review the scope of the cancer problem, describe the basis of antitumor immunity, and introduce the concept of tumor immunotherapy.

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The Role of Exhaustion in Tumor-Induced T Cell Dysfunction in Cancer,e will review the concept of T cell exhaustion; the mechanisms involved; the markers employed for the identification of exhausted T cells; the evidence for cancer-induced exhaustion, in particular in lung cancer; and the implications of this phenomenon on tumor immunology.

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Regulatory T Cells and Th17 Cells in Cancer Microenvironment,d cancer types significantly affect the numbers and functions of the two T-cell subsets in tumors. Tumor microenvironments that regulate migration and population of FoxP3. T cells and Th17 cells in tumors and associated lymphoid tissues are discussed in this chapter.

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Role of Plasmacytoid Dendritic Cells in Cancer,portant necessity and will pave the road to novel therapeutic strategies to fight malignancies. In this chapter we will discuss novel findings about the therapeutic tools which are based on the pharmacological manipulation of tumor-associated pDCs.

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Autophagy and Necroptosis in Cancer,nd summarizes the current state of development of novel therapeutics in various phases of clinical trials. In addition, crosstalks in apoptosis, autophagy, and necroptosis signaling pathways and future treatment strategies will be reviewed.

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SAGE

Nima RezaeiUp-to-date review of cancer immunology.Bench to bedside approach to the immunology of cancers, with a focus on clinical aspects in order to educate clinicians in the clinical implications of recent re

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https://doi.org/10.1007/978-3-662-44006-3Cancer Immunotherapy; Cancer immunology; Translational Medicine