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Titlebook: Cancer Gene Therapy; Past Achievements an Nagy A. Habib Book 2002 The Editor(s) (if applicable) and The Author(s), under exclusive license

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Human , Transcriptional Regulatory Sequencesf genes can be expressed in an HCC-specific manner under the control of the AFP regulatory sequences . and .. It would appear that, with the development of a suitable delivery system, HCC-directed gene therapy using the AFP regulatory sequences holds a promising future.
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Polyoma and Papilloma Virus Vectors For Cancer Gene Therapyhe systems require further attention. Present vectors vary widely in efficacy of DNA transfer, and parameters important in regulating this process need to be more clearly defined. Following establishment of a generalised prototype, modifications could then be made to target specifically to tumours,
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Killer/DR5, A Novel DNA-Damage Inducible Death Receptor Gene, Links the p53-Tumor Suppressor to Casp apoptosis through caspase activation through an as yet unclear signaling pathway that does not require the FADD adaptor. The TRAIL receptor KILLER/DR5, is induced by DNA damage and appears to be regulated by the tumor suppressor gene p53. Both the Fas receptor and KILLER/DR5 provide potential links
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