Titlebook: Cancer Drug Discovery; Science and History Kyu-Won Kim,Jae Kyung Roh,Chan Kim Book 2016 Springer Science+Business Media Dordrecht 2016 Hist

远足

Advancements in Life Sciences and Characteristic Features of Cancer Cellsin 1953, when the double helix structure of DNA—the genetic material that transmits cellular characteristics to the next generation—was elucidated by Watson and Crick. Subsequently, advances in the understanding of the functions and mechanisms of cells were made rapidly.

Noisome

Antimetabolic Anticancer Drugsorporated into DNA, which inhibits DNA synthesis (Fig. 5.1). Therefore, these drugs are largely classified into folic acid derivatives that inhibit enzymes of folate pathway such as dihydrofolate reductase (DHFR), pyrimidine or purine derivatives that inhibit pyrimidine or purine synthesis, and direct inhibitors of DNA synthesis (Fig. 5.2).

cloture

Natural Product Anticancer Drugsbule function of spindle fibers, which is related to chromosome segregation, while podophyllotoxin derivatives, camptothecin derivatives, and other antibiotics cleave DNA bases, causing DNA damage through the suppression of topoisomerase I or II and the production of free radicals.

Free-Radical

Hormonal Anticancer Drugsdecades of basic research in the field of cancer biology. Another example of an anticancer drug that was successfully developed after understanding the biological characteristics of a specific cancer is the hormonal anticancer drug.

Aspirin

Agronomy

Carcinogen

Neutrinos, Dunkle Materie und Co.Immunotherapeutic anticancer agents eliminate cancer cells by acting on the immune system and activating the immune response against cancer cells. This class of drugs includes cytokines such as INFγ and IL2, nonspecific immune stimulants BCG and levamisole, and recently developed anti-CTLA-4 monoclonal antibody ipilumumab.

Agnosia

Chalcopyrite Thin-Film Solar-Cell DevicesThe parallel development of life science and cancer treatment after the introduction of the cell theory in 1838 can be briefly summarized as shown in Fig. 11.1. In the mid-1850s, cancer entered the field of science after being designated as neoplasm, which is defined as a new mass of cells created from the division of tumor cells.

insightful

Immunotherapeutic Anticancer Drugs and Other Miscellaneous Anticancer DrugsImmunotherapeutic anticancer agents eliminate cancer cells by acting on the immune system and activating the immune response against cancer cells. This class of drugs includes cytokines such as INFγ and IL2, nonspecific immune stimulants BCG and levamisole, and recently developed anti-CTLA-4 monoclonal antibody ipilumumab.

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