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Titlebook: Cancer Clinical Trials; A Critical Appraisal Hans Scheurlen,Richard Kay,Michael Baum Conference proceedings 1988 Springer-Verlag Berlin Hei

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The Design of Cancer Prevention Trials planning stages in order to illustrate some special design considerations that arise in these trials. Finally, I will summarize what seem to me to be some of the major differences between treatment and prevention trials.
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Combining Randomized and Nonrandomized Patients in the Statistical Analysis of Clinical Trialserapy to be chosen based on their own or their physician’s judgement, because they don’t like the protocol requirements of the trial, or simply because they are not in an area where a trial is being conducted. To have external validity, the trial results must be applicable to eligible patients who were not enrolled.
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Randomization and Follow-up Care of Patients in a Breast Cancer Clinical Trial: Personal Experienceand to assess it in comparison with the results of larger hospitals and centers. We can discipline our thinking and make a contribution to answering critical questions only on the basis of participation in clinical studies.
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M. Gerlach,W. Gsell,P. Riederer groups can be used reliably to compare treatments. Since I have already presented my ideas in writing several times, I will merely summarize them briefly here and refer interested readers to the list of references at the end of the contribution, where my previous papers as well as those of some other authors are listed.
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Treatment Decisions in Breast Cancereast cancer reported no consensus in respect of primary surgery, pattern of referral for postoperative radiotherapy or the use of adjuvant systemic treatment. This lack of consensus could, however, have derived from differences in disease presentation, as seen by different surgeons.
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Haley E. Melikian,Sijia Wu,Luke R. Gabrielnderstand our present situation, it might be helpful to survey the historical development of clinical trials and to consider what was the basis for decisions in therapeutics before, or still is concomitant with, the introduction of such clinical trials.
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