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Titlebook: Cancer Clinical Trials; A Critical Appraisal Hans Scheurlen,Richard Kay,Michael Baum Conference proceedings 1988 Springer-Verlag Berlin Hei

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书目名称Cancer Clinical Trials
副标题A Critical Appraisal
编辑Hans Scheurlen,Richard Kay,Michael Baum
视频video
丛书名称Recent Results in Cancer Research
图书封面Titlebook: Cancer Clinical Trials; A Critical Appraisal Hans Scheurlen,Richard Kay,Michael Baum Conference proceedings 1988 Springer-Verlag Berlin Hei
描述The controlled clinical trial has become an essential part of the clinician‘s decision-making process. Clinical trials, however, still raise methodological problems that are important and at the same time controversial: subgroup analysis and interactions, meta-analy­ sis of similar trials, consideration of subjective clinical opinions and those of the public at large, assessment of quality of life, pre­ vention trials, and so on. In February 1987 we took our third step along the road to evaluating these issues in dialogues between cli­ nicians, psychologists, legal experts, and statisticians. The talks presented at the meeting were revised by the authors afterwards and have been rearranged by the editors to form a strictly organ­ 1 2 ized book. The two preceding meetings in 1978 and 1981 focused strongly on adjuvant therapy in primary breast cancer, but this top­ ic served merely as a nucleus in the third meeting. This meeting, although called the Third Heidelberg Symposium was forced to leave Heidelberg and in fact was held in Freiburg. Without the interest and enthusiasm of Professor Martin Schu­ macher and his colleagues in Freiburg the meeting would never have taken place. The
出版日期Conference proceedings 1988
关键词adjuvant therapy; breast cancer; cancer; cancer prevention; cancer treatment; clinical trial; morbidity; pr
版次1
doihttps://doi.org/10.1007/978-3-642-83419-6
isbn_softcover978-3-642-83421-9
isbn_ebook978-3-642-83419-6Series ISSN 0080-0015 Series E-ISSN 2197-6767
issn_series 0080-0015
copyrightSpringer-Verlag Berlin Heidelberg 1988
The information of publication is updating

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Randomised Trials: The Case for Science in Medicinesy to understand. Epistemology is the study of the growth of knowledge, or “how do we know what we think we know”? What I would now like to try to get across is that scientific philosophy is not a rarefied activity indulged in by retired physicians who have nothing better to do with the remainder of
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Statistical Standards for Protocols and Protocol Deviationscularly so as the number of staff increases because of the need to control standards and to maintain consistent approaches. Statistical work is no exception, whether concerned with the design or the analysis of clinical trials.
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The Design of Cancer Prevention Trialscompleted and only a few dozen such trials are currently underway in the entire world. This situation contrasts sharply with that for cardiovascular disease, where large-scale randomized intervention trials have been used as a method of study for several decades. In this article I want to show how t
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Significance Testing in the Comparison of Survival Curves from Clinical Trials of Cancer Treatment prolonged follow-up. The test is optimal when the death rate in one group consistently exceeds that in the other group by a given proportion, the so-called proportional hazards situation. Alternative tests that are sometimes used are Gehan’s generalisation of the Wilcoxon rank sum test (Gehan 1965)
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Treatment by Protocol: Assessment of Gains and Losses disease in mind, based on available evidence accumulated so far, one first of all has to weigh costs, risks, and benefits of all feasible interventions. Diagnostic procedures prior to remedial interventions and subsequent differential treatments should be specified in advance. Finally, an attempt s
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