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Titlebook: Cancer Clinical Trials; A Critical Appraisal Hans Scheurlen,Richard Kay,Michael Baum Conference proceedings 1988 Springer-Verlag Berlin Hei

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Treatment by Protocol: Assessment of Gains and Losseshould be made to account for the outcome of an intervention. In a broad sense, it is this three-point statement — background information, strategy for actions, strategy for analyzing results — that constitutes a protocol. Any intervention by protocol may be called a therapy.
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Limitations and Advantages of Meta-analysis in Clinical Trialsgeneral hypothesis by combining data from related studies, estimation of a general treatment effect by combining data from related studies, generation of hypotheses for further testing, and convincing others of a finding by presenting a systematic summary of all studies related to that finding.
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Helmut Beckmann,Michael Osterheider was a randomized option after all patients had received a radical mastectomy, but it was also supported by the King’s/CRC trial of simple mastectomy with or without radiotherapy. Overall, the death rate after 10 years among 10-year survivors was estimated to be 35% higher (95% CI, 15%–58%) in those who had been randomized to receive radiotherapy.
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https://doi.org/10.1007/978-3-7091-3345-3 planning stages in order to illustrate some special design considerations that arise in these trials. Finally, I will summarize what seem to me to be some of the major differences between treatment and prevention trials.
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Massimo Avoli,Tomás A. Reader,Pierre Gloorerapy to be chosen based on their own or their physician’s judgement, because they don’t like the protocol requirements of the trial, or simply because they are not in an area where a trial is being conducted. To have external validity, the trial results must be applicable to eligible patients who were not enrolled.
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