Titlebook: Calcium in Drug Action; George B. Weiss Book 1978 Plenum Press, New York 1978 Prostaglandin.calcium.drug.metabolism.pharmacology.research

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Effects of Opiate Drugs on the Metabolism of Calcium in Synaptic Tissueer with changes in body temperature may be observed after a single dose of the opiate agonist. However, repeated administration of the drug at a constant dose or the necessity to increase the dose to achieve the same degree of response produces an effect commonly referred to as tolerance. This effec

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Role of Calcium in Desensitization at the Motor End-Plate of Skeletal Musclendergoes a rapid increase in ionic conductance as the cholinergic receptors are activated. This agonist-induced increase in ionic conductance remains for a short period and then reverses even though the agonist application is continued. Thesleff (1955) initially studied this phenomenon using intrace

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Effect of Pharmacological Agents on Calcium Stores in Amphibian Fast and Slow Muscle Fibersto study drug effects on cellular Ca. metabolism. The amphibian slow muscle fiber contains multiple end plates, is innervated by small nerve fibers, and gives a graded tonic response to repetitive neural stimulation. Tension is regulated by graded levels of depolarization of the surface membrane (Ku

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Calcium Related Basis of Action of Vascular Agents: Cellular Approachesf muscle (Bianchi, 1975; Ebashi, 1977) that calcium serves as a link in the events leading from membrane depolarization to muscle contraction. However, the degree of dependence on the extracellular Ca. level varies greatly among the different types of muscle. For example, contractile responsiveness

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https://doi.org/10.1007/978-3-531-90169-5nt to this observation, it has been increasingly recognized that Ca. plays a critical and central role in a multitude of biological events at both the intra-and extracellular levels (Duncan, 1976; Kretsinger, 1976a; Table 1). However, Ca. distribution across the cell membrane is far from equilibrium