| 书目名称 | CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential | | 编辑 | R.W. Compans,M.D. Cooper,Elisabeth Suri-Payer | | 视频video | http://file.papertrans.cn/221/220237/220237.mp4 | | 概述 | Includes supplementary material: | | 丛书名称 | Current Topics in Microbiology and Immunology | | 图书封面 |  | | 描述 | .The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body’s own constituents thus preserving its integrity. Multiple mechanisms work in concert to ensure self-tolerance. Apart from purging the T cell repertoire from auto-reactive T cells via negative selection in the thymus dominant tolerance exerted by regulatory T cells plays a major role in tolerance imposition and maintenance. Among the various regulatory/suppressive cells hitherto described, CD4.+.CD25.+. regulatory T cells (Treg) and interleukin-10 producing T regulatory 1 (Tr1) cells have been studied in most detail and are the subject of most articles in this issue. Treg, also called "natural" regulatory T cells, will be traced from their intra-thymic origin to the site of their action in peripheral lymphoid organs and tissues. ..The repertoire of Treg is clearly biased towards recognition of self-antigens, thereby potentially preventing autoimmune diseases such as gastritis and oophoritis. Regulatory T cells, however also control infections, allergies and tolerance to transplanted tissues and this requires their induction in the periphery under cond | | 出版日期 | Book 2005 | | 关键词 | Antigen; T cell; Transplant Survival; autoimmune disease; cancer; cell; cell biology; dendritic cells; disea | | 版次 | 1 | | doi | https://doi.org/10.1007/3-540-27702-1 | | isbn_softcover | 978-3-642-06376-3 | | isbn_ebook | 978-3-540-27702-6Series ISSN 0070-217X Series E-ISSN 2196-9965 | | issn_series | 0070-217X | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE |
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