Titlebook: CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential; R.W. Compans,M.D. Cooper,Elisabeth Suri-Payer Book 2005 The Edit

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Friedrich Schreiber,Michael Wolffsohnlerance, in averting autoimmune responses as well as in controlling inflammatory reactions. However, a number of fundamental questions concerning their origin, mechanism of action, and the sites of suppression remain elusive and are currently a matter of debate. Notably, the potential heterogeneity

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https://doi.org/10.1007/978-3-322-95534-0gies to harness their immunoregulatory effects. This review will discuss the similarities and differences between human Tr1 and naturally occurring CD4.CD25. Tr cells, as well as evidence that indicates that they have nonoverlapping, but synergistic roles in immune homeostasis.

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Selection and Behavior of CD4+ CD25+ T Cells In Vivo: Lessons from T Cell Receptor Transgenic Modelsadoptive transfer of small numbers of ex vivo isolated TCR transgenic suppressor T cells allows for the visualization of the fate of such cells when confronted with cognate antigen in a quasi-normal, nonlymphopenic environment. Characteristic features of the currently available TCR transgenic models

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Peripheral Generation and Function of CD4+CD25+ Regulatory T Cellsation and function of CD4.CD25. regulatory T cells. CD4.CD25. regulatory cells were originally described as thymus-derived anergic/suppressive T cells. Recent papers, however, indicate that these cells might also be generated in the periphery. CD4.CD25. regulatory T cells can be activated by self- a

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