Titlebook: CCN proteins in health and disease; An overview of the F Annick Perbal,Masaharu Takigawa,Bernard Perbal Book 2010 Springer Science+Business

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Global Expression Profiling Reveals a Role for CTGF/CCN2 in Lactogenic Differentiation of Mouse Mamand apoptosis. HC11 mouse mammary epithelial cells, which are capable of lactogen-induced differentiation in cell culture, were used to follow the changes in gene expression during this process. The expression profiles of over 20,000 genes were compared in HC11 cells undergoing lactogenic differenti

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Inhibitors of Connective Tissue Growth Factor (CCN2)-Mediated Fibrogenesis: Underlying Mechanisms aeam of transforming growth factor beta (TGF-β)-mediated intracellular signaling. In recent years the role of CCN2 in fibrogenic pathways has been explored by experimentally attenuating its production or action through the use of pharmacological inhibitors, neutralizing antibodies, antisense oligonuc

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CCN6 Regulates Breast Cancer Growth and Invasion Through Modulation of IGF Signaling and Epithelialhomeostatic biological processes. Matricellular proteins, which include the CCN family of proteins, have the ability to coordinate the extracellular and intracellular signaling pathways and thus modulate the cross-talk between the microenvironment, epithelial and mesenchymal cells. Our laboratory ha

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https://doi.org/10.1007/978-3-8350-5541-4CN2 gene transcription exclusively in tubular epithelial cells stimulated with TGF-β1. Although further studies are necessary, the regulatory PARP-1/PBE complex seems to be a promising target for anti-fibrotic therapy.

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Gunda Huskobla,Matthias Jakob,Jörg Neumannat CCN3 downregulates osteogenesis by two different pathways: suppression of BMP and stimulation of Notch. This effect was also transmitted to osteoblasts in separate cultures, which indicates the paracrine manner of CCN3 activity. CCN3 may also affect the extracellular environment of the niche for hematopoietic stem cells.