Titlebook: Brain Aging and Therapeutic Interventions; Mahendra K. Thakur,Suresh I.S. Rattan Book 2012 Springer Science+Business Media Dordrecht 2012

旧式步枪

https://doi.org/10.1007/978-3-8348-9007-8ly controlled and standardized. The challenge is even greater when targeting human cognitive function, a multi faceted process which is demanding to measure and hard to improve. However, good progress is being made in this field; standardized cognitive tests are available and gold-standard experimen

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Brain Aging: A Critical Reappraisal,ticity, perturbed calcium homeostasis, neuronal survival and neuroinflammation, eventually affecting brain functions with increased incidence of neurological disorders. Factors like stress, depression, hypertension as well as obesity accelerate the aging of brain contributing to neurodegeneration an

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Base Excision DNA Repair: The House Keeping Guardian for Genomic Stability in the Brain,in maintaining the structural integrity of DNA that is quite often threatened from events taking place within the cell itself. Implicit in this crucial role is also the fact that any perturbation in this repair pathway could lead to deleterious consequences—particularly in a post-mitotic tissue like

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,Brain Aging: Influence of Early–Life Events on Late-Life Brain Disorders,ly later in life, if an additional perturbation were to occur. The LEARn model postulates latent expression of specific genes triggered at an early stage of life. The LEARn model operates via the regulatory region (promoter) of the gene, specifically through changes in methylation and oxidation stat

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