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Titlebook: Brain Aging and Therapeutic Interventions; Mahendra K. Thakur,Suresh I.S. Rattan Book 2012 Springer Science+Business Media Dordrecht 2012

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Manfred Bornhofen,Martin C. Bornhofenotein and amyloid beta peptides in mitochondria in AD brain has been the subject of intense and interesting research and the review has described this aspect in the context of mitochondrial dysfunction. The cross-talk of mitochondrial dysfunction with oxidative stress and inflammatory response in AD
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https://doi.org/10.1007/978-3-658-13846-2al effects on sleep as well as age related diseases. This review aims to summarize the current knowledge on the changes of the circadian system in advanced age and the therapeutic effects of antioxidant melatonin on such changes.
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https://doi.org/10.1007/978-3-8348-9007-8 including our ICER mutant mice, is discussed. Finally, based on the developments emerging from research using genetically modified mice, potential molecular targets are proposed for ameliorating memory impairments and dementia.
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