Titlebook: Boundaries between Promotion and Progression during Carcinogenesis; Oscar Sudilovsky,Henry C. Pitot,Lance A. Liotta Book 1991 Plenum Press

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Summary by Moderator this interaction can modify the development or reversal of malignancy. In the case of ES cells produced in vitro from explanted embryos the moment of explantation could be considered as initiation. It is arguable whether there is any promotion or progression. It is, however, unquestionable that the

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Tumor Progression in Transgenic Mice Containing the Bovine Papillomavirus Genomeis. It has provided a tractable system to study and to dissect the multiple steps involved in carcinogenesis, essentially by fixing one of these steps.. In transgenic mice, DNA is introduced into the germ line and that gene is stably inherited to the offspring of the mice. Transgenic mice have been

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Differential Gene Expression During Tumor Promotion and Progression in the Mouse Skin Modelmor formation can be identified. Once operational definitions have been made, investigators can and should pursue questions of molecular mechanisms to explain phenotypic changes that occur during promotion and progression. This paper deals with the identification and characterization of molecular ma

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Oncogenes and Breast Cancer Progressionogical status of the host. Extensive studies have been undertaken to determine the relationship between these factors and tumor development in humans and experimental rodent models. Attempts to develop a cohesive picture of how these factors participate in mammary tumorigenesis have been hampered, i

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Gene Amplification During Stages of Carcinogenesiselated concepts of promotion and progression describe an essential feature of carcinogenesis, the gradual change from a normal cell to a tumor composed of proliferating, invading, metastasizing cells. Promotion is the gradual conversion of undetectable initiated cells to tumors without the continuin

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Recessive Mutations in Cancer Predisposition and Progressionf the present volume. There is a great deal of circumstantial evidence in its support which arises from examination of human populations.. There has been, for example, extensive documentation of familial aggregation of specific histological types of tumors, sometimes developing with the formal behav

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