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Titlebook: Boundaries between Promotion and Progression during Carcinogenesis; Oscar Sudilovsky,Henry C. Pitot,Lance A. Liotta Book 1991 Plenum Press

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Introduction: Is There a Boundary between Promotion and Progression?Gordon Conference on Cancer in August, 1987. It had become evident to me and other participants that the concepts of promotion and progression as two separate stages in a multi-step model of carcinogenesis required further evaluation.
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Characterization of the Stage of Progression in Hepatocarcinogenesis in the Rate stage of initiation as that which established “a persistent region of . whence tumors of varied kinds emerge at a later time”.. All of the remainder of neoplastic development he termed progression. In a sense, such a concept was quite analogous to that proposed earlier by several authors as the st
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Malignant Conversion, the First Stage in Progression, is Distinct from Phorbol Ester Promotion in Monogenesis.. Although skin tumors can be induced by repeated topical applications of a carcinogen., protocols have been developed which define at least three distinct stages: initiation, promotion and malignant conversion.. In a typical experiment, the first stage, initiation, is accomplished by a si
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Discussion of Sessionmotion and progression. Dr. Pitot, if I interpret him correctly, said that the effect of promoting agents can extend to cells in the stage of progression, while Dr. Slaga expressed the opinion that both processes exist as a continuum. So I would like to start the discussion by asking Dr. Pitot how h
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Progression in Teratocarcinomash (1953), and of recalling many pleasant and stimulating discussions with each of them. Foulds studied solid tumors, primarily adenocarcinomas of the breast, and his definition of progression as the independent and irreversible gain or loss of unit characters with time leading to the autonomous stat
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Developmental Potential of Murine Pluripotential Stem Cellsncluding the germ line.. As the ICM cells proliferate, groups of these cells become committed to specific developmental pathways. Pluripotential cells appear to persist in the embryonic portion of the embryo up until 7.5 days.. These undetermined pluripotent stem cells have been established as perma
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