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Titlebook: Blood Cells, Rheology, and Aging; Dieter Platt (Direktor) Conference proceedings 1988Latest edition Springer-Verlag Berlin Heidelberg 1988

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期刊全称Blood Cells, Rheology, and Aging
影响因子2023Dieter Platt (Direktor)
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图书封面Titlebook: Blood Cells, Rheology, and Aging;  Dieter Platt (Direktor) Conference proceedings 1988Latest edition Springer-Verlag Berlin Heidelberg 1988
影响因子In the third Erlangen-Nuremberg symposium on experimental geronto­ logy we discussed the effect of aging on blood cells and rheology. Most studies with red cells have been performed on humans, rats, and rabbits. All these erythrocytes have no nucleus; the cells are therefore a model in which new synthesis of proteins is impossible. All the processes are age dependent except for exchange with the plasma. Investigations of red cells have attracted attention because of the latter‘s availability in large quantities from biochemists, physiologists, immunologists, and micro­ scopists. We now have a relative abundance of data on the biochemical and immunologic composition as well as on the ultrastructure of the cells. The second topic under discussion at the symposium was the immune system and cell receptors. One of the most apparent features of aging of the organism is progressive dysregulation of the immune system. As a result, the incidence of infection, cancer, and autoimmune and immune complex diseases increases. While we have a lot of new data on the function and differentiation of lymphoid cells, we have little informa­ tion on lymphocyte receptors during the aging process. Rheolog
Pindex Conference proceedings 1988Latest edition
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tudies with red cells have been performed on humans, rats, and rabbits. All these erythrocytes have no nucleus; the cells are therefore a model in which new synthesis of proteins is impossible. All the processes are age dependent except for exchange with the plasma. Investigations of red cells have
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Stefania Saviolo,Antonio Marazzaverage life span or “life expectancy” is influenced at least as much by environment, lifestyle, or health habits as by genetic endowment. These actuarial distinctions are important in understanding aging as a biologic phenomenon reflected in survival patterns.
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Regulation of the Immune and Nonimmune Aging Process by the Major Histocompatibility Complex,verage life span or “life expectancy” is influenced at least as much by environment, lifestyle, or health habits as by genetic endowment. These actuarial distinctions are important in understanding aging as a biologic phenomenon reflected in survival patterns.
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Receptor and Postreceptor Changes During Lymphocyte Aging,reduced sensitivity to the stimulatory agent, a longer time to respond, etc. (Roth and Hess 1982). The lymphocyte serves as a useful system for examining such age-related alterations for a number of reasons (Adler and Nordin 1981; Kay and Makinodan 1981):
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