Titlebook: Biomedical Translational Research; Drug Design and Disc R.C. Sobti,Naranjan S. Dhalla Book 2022 The Editor(s) (if applicable) and The Autho

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Computational Methods for Drug Repurposingproved drugs to treat the disease and several other drugs which are not toxic to humans but failed to treat the diseases. In silico approaches for analyzing and integrating large-scale genomic datasets have been incorporated in the drug repurposing methodologies. Here, we focus on describing existin

Corporeal

Genomic Approaches for Drug Repositioningolecular docking, genome-wide association studies, and network-based approaches aided by artificial intelligence will be described in this chapter along with research examples that have used these methods. Drug repositioning for certain diseases, such as Alzheimer’s disease, cystic fibrosis, and SAR

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Organ-on-a-Chip: Novel In Vitro Model for Drug Discoveryimensional (3D) in vitro model is 3D bioprinting, which makes realistic in vitro disease models and mimics the actual cellular arrangement of any human tissue or organ. Organ-on-a-chip as 3D in vitro model has shown its potential to understand the disease mechanism along with evaluation of new thera

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Biomarker-Based Drug Discovery with Reverse Translational Approachedside to bench/clinics to laboratories’ instead of ‘bench to bedside/laboratories to clinics’. It is a science of integrating and understanding the mechanism of action ‘man to mice to molecule’ through multiple levels of safety, efficacy and acceptability based on relevant science. The concept of r

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Nanoparticles: A Potential Breakthrough in Counteracting Multidrug-Resistant Bacterial Infections—A the public health. Apart from this, biofilm-associated infections have also significantly reduced the efficacy of currently imparted antibacterial remedial therapy, thus leaving no viable therapeutic option available. This alarming situation thus calls for the development of and designing novel alt

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Nanodrugs: A Futuristic Approach for Treating Nephrolithiasisveral nanoparticles such as those made up of metals or metal oxides besides lipid and polymer encapsulated nanoparticles have been reported lately for targeting kidney stones. The present article discusses the current challenges and futuristic approaches for the development of nanoparticles of oxala

Alveolar-Bone

Lipodermaceuticals: Technological Transformationschnologies could be promising for the delivery of the drug into the deeper tissues. The present book chapter deals with various aspects which are pertinent for the development and translation of such carrier systems.

Meditative

The Importance of Drug Dose Adjustment in Elderly Patients with Special Considerations for Patients st of the physiological functions, including drug metabolizing and excretory capacity declines in the elderly, consequently cause significant alterations in the metabolic disposition as well as changes in the pharmacokinetic (PK) and pharmacodynamic (PD) parameters of administered drugs in elderly s