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Titlebook: Biology of the Lysosome; John B. Lloyd,Robert W. Mason Book 1996 Springer Science+Business Media New York 1996 biology.metabolism.nucleic

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Acidification of Lysosomes and Endosomesan-type equilibrium. Considerable experimental work over the past 15 years has elucidated the mechanisms for acidification of intracellular organelles, including lysosomes and endosomes, and current investigative efforts are focused at understanding regulation of the acidification mechanism.
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Selective Proteolysis: 70-kDa Heat-Shock Protein and Ubiquitin-Dependent Mechanisms? rate-limiting step in the lysosomal degradation of cytoplasmic proteins must be their initial sequestration. Indeed, the initial sequestration serves to remove cytoplasmic proteins from their functional site in the cell. Bulk sequestration of cytoplasm (macro-autophagy), described elsewhere in this
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Lysosomal Metabolism of Proteinsrett and Kirschke, 1981). Detailed characteristics are known for several of the enzymes involved in lysosomal proteolysis, although recent data suggest that the current catalog of enzymes involved in protein degradation is by no means complete. Although the enzymes are the necessary tools for hydrol
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