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Titlebook: Biology of Vascular Smooth Muscle: Vasoconstriction and Dilatation; Yuansheng Gao Book 20171st edition Springer Nature Singapore Pte Ltd.

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Electrical and Mechanical Properties of Vascular Smooth Muscleting membrane potentials of VSM cells, although being mainly determined by the equilibrium potential of K., are markedly affected by a high concentration of intracellular Cl.. The changes in membrane potentials associated with vasoconstriction are often graded depolarization rather than in action po
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Neurotransmitters sympathetic, parasympathetic, and sensory-motor nerves. These neurotransmitters exert their effects mostly by binding to the G-protein-coupled receptors (GPCRs), which trigger the dissociation of the α-subunit of the G-protein from the βγ-subunits followed by the activation of their downstream effe
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Endothelium-Derived Factorsderived hyperpolarizing factor (EDHF), and endothelin-1 (ET-1). The former three are vasodilators, while ET-1 is a potent vasoconstrictor. NO and PGI. exert their effects primarily by activating, respectively, cGMP–cGMP-dependent protein kinase (PKG) and cAMP–cAMP-dependent pathways, which result in
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Shear Stress, Myogenic Response, and Blood Flow Autoregulation against the endothelial layer termed as shear stress and a force perpendicular to the vessel wall resulted from blood pressure termed as tensile stress. Shear stress is sensed by various types of ion channels and membrane receptors as well as adhesion proteins, glycocalyx, and primary cilia on the
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