Titlebook: Biology of Growth Factors; Molecular Biology, O Jeffrey E. Kudlow,David H. MacLennan,Avrum I. Gotl Book 1988 The Editor(s) (if applicable)

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Molecular and Developmental Biology Aspects of Fibroblast Growth Factor identified by its ability to cause the proliferation and delayed differentiation of myoblasts (Gospodarowicz et al.,1975). It was later rediscovered on the basis of its ability to stimulate endothelial cell proliferation (Lemmon et al.,1982; Maciag et al.,1978).

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978-1-4757-1982-6The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines

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Ina Grau,Ravena Penning,Hans-Jürgen Andreßthe source of the growth activity present in serum. Partially purified fractions that contained mitogenic activity were isolated, but none of these demonstrated the cellular source of this proliferative activity. In 1974, it was observed that platelets were the source of the principal mitogenic acti

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Henriette Meissner,Alexander Schrehardtewed in 1–2). Following the purification of the EGF-receptor,. and its partial sequencing,. the complete primary structure of the EGF-receptor was deduced from nucleotide sequence of cDNA clones.. The mature receptor is composed of 1,186 amino acid residues that are preceded at the NH.-terminal end