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Titlebook: Biology of Growth Factors; Molecular Biology, O Jeffrey E. Kudlow,David H. MacLennan,Avrum I. Gotl Book 1988 The Editor(s) (if applicable)

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期刊全称Biology of Growth Factors
期刊简称Molecular Biology, O
影响因子2023Jeffrey E. Kudlow,David H. MacLennan,Avrum I. Gotl
视频video
学科分类Advances in Experimental Medicine and Biology
图书封面Titlebook: Biology of Growth Factors; Molecular Biology, O Jeffrey E. Kudlow,David H. MacLennan,Avrum I. Gotl Book 1988 The Editor(s) (if applicable)
影响因子Growth factors are elaborated to control the growth of cells in such physiological processes as wound healing, tissue regeneration and the immune response. Abnormal production of these growth factors, their receptors or intracellular med!ators of their action may lead to disease states including oncogenesis. This volume will focus on exciting developments in defining the precise molecular lesions that permit the conversion of controlled proliferative signals to neoplasia, on the possible involvement of growth factors in the development of blood vessel diseases as seen in diabetes and atherosclerosis, on the altered immune surveillance that leads to autoimmunity and on the fundamental mechanisms by which growth factors signal their target cells. We expect that the contents of this volume will help promote understanding of the role of these fundamental biological processes and their alterations in a wide variety of disease states and stimulate new investi­ gations in this important area of biomedical research. The Editors v CONTENTS PERSPECTIVES ON THE CONTROL OF GROWTH AND DIFFERENTIATION Perspectives on the Biology of Growth Factors . . . •. . . . . . . . . . . . . . . • I. B. Frit
Pindex Book 1988
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Structural and Functional Studies of Protein Kinase Cn which possesses serine/threonine protein kinase activity. To further characterize the function of PKC, we have generated a series of rat fibroblast cell lines which stably overexpress a full-length cDNA encoding the .1 form of this enzyme. These cell lines contain a 20- to 53-fold increase in PKC
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,Serviceentgeltkonzepte im Personengeschäft,B chain of PDGF and presumably exerts its transforming effects through interaction with the normal PDGF receptor (Doolittle et al., 1983; Waterfield et al., 1983; Huang et al., 1984). Constitutive expression of TGF-α and of EGF, both of which bind to the EGF receptor, also results in cell transforma
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https://doi.org/10.33283/978-3-86298-627-9e or more membrane or cytosolic proteins which catalyze subsequent changes in the activities of key enzymes. The identification of such cellular substrate(s) for the insulin receptor kinase, or for the receptor kinase of other growth factors, is an important step to understanding the mechanism of ac
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0065-2598 NTENTS PERSPECTIVES ON THE CONTROL OF GROWTH AND DIFFERENTIATION Perspectives on the Biology of Growth Factors . . . •. . . . . . . . . . . . . . . • I. B. Frit978-1-4757-1982-6978-1-4757-1980-2Series ISSN 0065-2598 Series E-ISSN 2214-8019
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