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Titlebook: Biological Toxins and Bioterrorism; P. Gopalakrishnakone Living reference work 20200th edition

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Botulinum Neurotoxin Antidotes,of a 100 kDa heavy chain (Hc) and a 50 kDa light chain (Lc) linked by a single disulfide bond. BoNT Hc binds to its receptors on the neural membrane and sets the stage for endocytosis at the motor nerve terminals (MNTs). Within early endosomes BoNT undergoes pH-dependent separation of the Hc and Lc.
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Structure, Genetics, and Mode of Disease of Cholera Toxin,n called cholera toxin (CT) which is largely responsible for the disease. CT consists of one enzymatically active A-subunit and five immunogenic B-subunits. The B-subunits form a symmetrical pentamer into which A chain sits on the top creating a wedge-shaped structure. Both A- and B-subunits are enc
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Mycotoxins, foods derived from plants can be infected by fungi during growing of the plants, harvest, and storage of the food; therefore, exposure to mycotoxins can easily occur in human populations. Researchers have special focus on mycotoxins because of their toxic effects in both animals and humans. Althoug
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Aflatoxins, a fused dihydrofurofuran moiety which are produced by . and . fungi. AF contamination can occur in various commodities including cereals, nuts, dried fruits, cocoas, oil seeds, spices, and copras in the field and/or during storage. The toxicological consequences of AF in populations are quite varie
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Marine Biotoxins in History: Misuse and Mayhem,uicide, attempt, or successfully commit murder, and STX has been officially declared a chemical weapon by the world’s governments. This meant that it was no longer a natural marine chemical of interest to toxinologists, pharmacologists, and at times seafood producers (because it can taint their prod
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Biosecurity and Toxins,se biotoxins as bioterror agents, including their high potency, the relatively long latency period before symptoms are manifested, the difficulty in detecting or diagnosing their presence and identity, and their relative ease in production and stability in the environment. All of these features also
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Toxins and Food Safety,parasites, and viruses) and toxins from natural source and microorganisms. Toxins are lethal to humans and vary in severity based on their interaction to target sites. They can be either non-proteinaceous small molecule or peptides and proteins. Some important toxins derived from bacteria (e.g., bot
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