Titlebook: Biological Reactive Intermediates; Formation, Toxicity, David J. Jollow,James J. Kocsis,Thomas Walle Book 1977 Springer Science+Business Me

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https://doi.org/10.1007/978-3-658-30335-8cent years. It is now appreciated that reactive alkylating, arylating, or acylating derivatives may arise during the metabolism of xenobiotics and that the covalent binding of these reactive metabolites to cellular macromolecules may initiate events leading to the destruction of specific cellular co

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Klimawirksame Kennzahlen Band II enzyme(s) responsible for the oxidation of benzpyrene to be located in the microsomal fraction of the liver. In that study it was shown that the enzyme system required both NADPH and molecular oxygen to function, and produced a number of mono- and dihydroxy products.

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Klimawirksame Kennzahlen Band IIized that most benzpyrene hydroxylase assays monitor the appearance of a fluorescent metabolite, despite the lack of stoichiometric relationship between the fluorescent compounds produced and the disappearance of benzpyrene. It has been shown that fluorescent metabolites other than the 3-hydroxy der

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Klimawirksame Kennzahlen Band II, the initial biogical receptors for the hydrocarbons have been identified as the microsomal mixed-function oxygenases. The polycyclic aromatic hydrocarbons are initially oxygenated by this enzyme system and the metabolites formed can be further oxygenated by the same mixed-function oxygenases. Othe

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Energiewirtschaftliche Analyse,h DNA had been added, his group had observed the same peaks of metabolite—DNA complexes as those obtained by Nebert’s group. However, the first four peaks were not identified by Brookes’ group, as they considered these minimal in both size and importance. Peak A of Brookes, therefore, corresponds to

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Klimawirksame Kennzahlen für Amerikathan by the unchanged compounds themselves. For example, bromobenzene and other halogenated hydrocarbons are converted to reactive epoxides by the action of a drug-oxidizing monooxygenase system in the liver and other tissues, with resultant liver injury (1,2). Most carcinogenic substances, e.g., ac