Titlebook: Biological Reactive Intermediates; Formation, Toxicity, David J. Jollow,James J. Kocsis,Thomas Walle Book 1977 Springer Science+Business Me

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Metabolic Activation of Methyldopa by Cytochrome P450-Generated Superoxide Anionduces mild, clinically covert hepatic injury in more than 15% of recipients when liver function tests are monitored (5), and thus the injury is not restricted to rare, idiosyncratic individuals. To determine if the toxicity produced by MD might be due to a reactive intermediate, [.H] MD was incubated with liver microsomes.

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https://doi.org/10.1007/978-3-658-25827-6ng metabolic inhibitors, but that CN is not a good inhibitor for this purpose. The oxidation of ethanol has not been proven to be mediated by a species of P450 which ethanol induces; however, this P450 does differ from the types of P450 inhibited by metyrapone and 7,8-benzoflavone (see text).

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