Titlebook: Biobetters; Protein Engineering Amy Rosenberg,Barthélemy Demeule Book 2015 American Association of Pharmaceutical Scientists 2015 drug tar

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Walter Prenowitz,James Jantosciakd/or high dosing to achieve clinical efficacy. A favorite strategy to create biobetters both from approved biologicals and based on new protein or peptide drug candidates is to prolong their time in circulation. This can be accomplished in two ways, either by conferring binding activity towards the

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Studies in History and Philosophy of Scienceof its glycoform for the successful treatment of patients with Gaucher disease. The steps involved in this endeavor and benefit of appropriately modified glucocerebrosidase for patients with Gaucher disease are chronicled.

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Book 2015 It is based on the fact that though numerous important therapeutic protein products have been developed for life threatening and chronic diseases that possess acceptable safety and efficacy profiles, these products have generally not been reexamined and modified for an improved clinical performance

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2210-7371 erapeutic enzymes and monoclonal antibodies - as examples of“Biobetters: Protein Engineering to Approach the Curative” discusses the optimization of protein therapeutic products for treatment of human diseases. It is based on the fact that though numerous important therapeutic protein products have

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https://doi.org/10.1007/978-3-658-04064-2obetters, and describe various strategies recently employed by biopharmaceutical firms. We conclude by considering issues involving immunogenicity of biologics, as well as controversies regarding whether biosimilars should have identical international non-proprietary names as the reference brand.

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Biosimilar and Biobetter Scenarios for the US and Europe: What Should We Expect?obetters, and describe various strategies recently employed by biopharmaceutical firms. We conclude by considering issues involving immunogenicity of biologics, as well as controversies regarding whether biosimilars should have identical international non-proprietary names as the reference brand.