Titlebook: Biobetters; Protein Engineering Amy Rosenberg,Barthélemy Demeule Book 2015 American Association of Pharmaceutical Scientists 2015 drug tar

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Restatement and Propositions (1968)ase (IDUA) lysosomal enzyme, and MPS Type II is caused by mutations in the iduronate 2-sulfatase (IDS) lysosomal enzyme. Both of these diseases have prominent CNS manifestations. This chapter describes biobetter forms of these recombinant enzymes, and the drug development of IgG-IDUA and IgG-IDS fus

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Event Handling with the Swing Component Set,us, in spite of having an effective treatment for Pompe disease, there remains a critical unmet medical need for a less immunogenic GAA, especially for CRIM-negative babies. New methods for inducing tolerance to GAA have been developed in recent years, which are reviewed here. They include drug-indu

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The New Synthese Historical Librarymixing Herceptin. and Avastin. in 5 % dextrose alone failed to reveal aggregates. However, mixing these formulations with human plasma resulted in the formation of large aggregates. No such aggregation was observed when the antibodies were formulated in 0.9 % NaCl and mixed with human plasma. The ag

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Lebensgeschichten aus der Wissenschaft-epitopes cross-react with native, unmodified proteins, breaking immune tolerance (Griffiths 2008; Omersel et al. 2008, 2011; van Beers et al. 2011; Sauerborn et al. 2010; Jiskoot et al. 2009; Schellekens and Jiskoot 2006). Here, autoantibody generation may lead to autoimmune disorders. Analogous to

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Vienna Circle Institute Yearbook and delivery and inform regarding potential liabilities that may be associated with the lead molecule. For biobetters, MA studies also ensure that the lead molecule is indeed “better” with respect to the selected attribute. This chapter outlines the MA strategy, the results of which dictate decisio

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https://doi.org/10.1057/9780230373440r efficacy profile (Foye, Lippincott Williams & Wilkins, Philadelphia, 2008). As a result of protein aggregation or degradation, therapeutic activity can be decreased, increased, or altered to have off-target effects. Protein degradation or aggregation could be facilitated under inflammatory circums