Titlebook: Behavioral Neurobiology of Bipolar Disorder and its Treatment; Husseini K. Manji,Carlos A. Zarate Jr. Book 2011 Springer-Verlag Berlin Hei

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Understanding Bipolar Disorder: The Epigenetic Perspective,s made BPD an appealing target for genetic studies yet, despite numerous attempts, the genetic basis of this disease remains elusive. Recently, it has come to light that epigenetic factors may also influence the development of BPD. These factors act via stable but reversible modifications of DNA and

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Clinical Endophenotypes for Bipolar Disorder,llness remains elusive. Given evidence that genes predisposing to BPD may be transmitted without expression of the clinical phenotype, interest has arisen in developing endophenotypes – indicators of processes mediating between genotype and phenotype. Patients with BPD have subtle neuropsychological

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Partial Rodent Genetic Models for Bipolar Disorder,bility to mood swings in euthymic BPD patients, and spontaneous cyclicity in at least some BPD patients. Currently, there is no rodent genetic model capable of encompassing the whole phenotype of BPD exists; however, recent genetic-behavioral studies have delineated partial models for some component

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The Role of the Aminergic Systems in the Pathophysiology of Bipolar Disorder, the aminergic system include serotonin (5-HT), norepinephrine (NE), dopamine (DA), and acetylcholine (ACh). By analyzing these neurotransmitters, this chapter highlights three hypotheses in the pathophysiology of BPD: the biogenic amine hypothesis, the cholinergic–aminergic balance hypothesis, and

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Mitochondrial Dysfunction and Bipolar Disorder,e roles of maternal inheritance, comorbidity with mitochondrial diseases, the mechanism of action of mood stabilizers, magnetic resonance spectroscopy, mitochondrial DNA mutations, gene expression analysis, and phenotypes of animal models. Mitochondrial dysfunction is not specific to BPD but is comm

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