Titlebook: Behavioral Neurobiology of Bipolar Disorder and its Treatment; Husseini K. Manji,Carlos A. Zarate Jr. Book 2011 Springer-Verlag Berlin Hei

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The Neurobiology of Bipolar Disorder: From Circuits to Cells to Molecular Regulation,ent points along a circuit like the trisynaptic pathway. Our ability to understand the functional implications in terms of complex molecular changes will ultimately influence our ability to develop novel treatments for BPD.

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Synaptic Plasticity in the Pathophysiology and Treatment of Bipolar Disorder,h in the hippocampus and also correlate with antidepressant-like behaviors. In contrast, inhibiting monoaminergic signaling, long-term stress, and pathophysiological concentrations of cytokines weakens glutamatergic synaptic strength in the hippocampus and is associated with depressive-like symptoms.

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Book 2011he development of animal models. Finally, the book covers treatment strategies for bipolar disorder, including both traditional and novel therapeutics, as well as non-pharmacological treatments. It offers both researchers and clinicians key insights into this devastating disorder.

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Husseini K. Manji,Carlos A. Zarate Jr.Covers a wide range of methodologies including neuroimaging, genetics and epigenetics, animal models, translational research and psychopharmacology.Describes the most effective currently available tre

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Behavioral Neurobiology of Bipolar Disorder and its Treatment978-3-642-15757-8Series ISSN 1866-3370 Series E-ISSN 1866-3389

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