Titlebook: Behavioral Neurobiology of Alcohol Addiction; Wolfgang H. Sommer,Rainer Spanagel Book 2013 The Editor(s) (if applicable) and The Author(s)

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Book 2013rought alcohol research substantially forward and influenced our thinking about how to reach our common paramount goal, namely to offer effective treatment solutions for an extensive group of patients with largely unmet medical needs..

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Signaling Pathways Mediating Alcohol Effects, exposure. In this chapter we review recent discoveries that demonstrate how ethanol alters signaling pathways involving several receptor tyrosine kinases and intracellular tyrosine and serine-threonine kinases, with consequences for regulation of cell surface receptor function, gene expression, pro

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Neurocircuitry Involved in the Development of Alcohol Addiction: The Dopamine System and its Accessevelopment of drug addiction. All major drugs of abuse, including ethanol, acutely activate the mesolimbic dopamine system. Both this acute drug-induced dopamine elevation, the dopamine elevations observed after presentations of drug-associated stimuli and alterations of dopamine function induced by

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What is in that Drink: The Biological Actions of Ethanol, Acetaldehyde, and Salsolinol,ues to be conducted in an effort to identify the biological basis of the reinforcing properties of alcohol in order to develop effective pharmacotherapeutic and behavioral interventions. One theory that has developed within the alcohol field over the past four decades postulates that the reinforcing

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Modeling the Diagnostic Criteria for Alcohol Dependence with Genetic Animal Models, of seven. AD risk can be traced to both genetic and environmental sources. Most genetic studies of AD risk implicitly assume that an AD diagnosis represents a single underlying genetic factor. We recently found that the criteria for an AD diagnosis represent three somewhat distinct genetic paths to

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Non-Human Primate Models of Alcohol-Related Phenotypes: The Influence of Genetic and Environmental rs influence alcohol consumption. The neurobiological systems that influence addiction vulnerability may do so by acting on alcohol response, reward pathways, behavioral dyscontrol, and vulnerability to stress and anxiety. Rhesus macaques show individual differences in alcohol response and temperame

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