Titlebook: Antiviral Innate Immunity; Chunfu Zheng Book 2025 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Sci

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Identifying RNA Sensors in Antiviral Innate Immunity,eceptors (PRRs), which detect Pathogen-Associated Molecular Patterns (PAMPs). Nucleic acids, including RNA and DNA, are recognized as particularly significant PAMPs, especially in the context of viral pathogens. During RNA virus infections, specific sequences in the viral RNA mark it as non-self, en

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DNA PAMPs as Molecular Tools for the cGAS-STING Signaling Pathways,ptors (PRRs) and their homologs, pathogen-associated molecular patterns (PAMPs), form the foundation for driving innate immune activation and the induction of immune responses during infection. In the context of DNA viruses or bacterial infections, specific DNA sequences are recognized and bound by

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In Vitro Cleavage Assay to Characterize DENV NS2B3 Antagonism of cGAS,ted by dsDNA from viral and bacterial origins as well as dsDNA leaked from damaged mitochondria and nucleus. Eventually, cGAS activation launches the cell into an antiviral state to restrict the replication of both DNA and RNA viruses. Throughout the long co-evolution, viruses devise many strategies

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Cryo-Electron Microscopy in the Study of Antiviral Innate Immunity,lenging samples, which are not readily available for traditional techniques. In particular, the strength of super macro-complexes and the lack of a need for crystals for cryo-EM make this technique feasible for the structural study of complexes involved in antiviral innate immunity. This chapter pre

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https://doi.org/10.1007/978-1-0716-4108-8Type I interferon (IFN-I) signaling pathway; Viral infections; Novel regulatory factors; CRISPR-mediate