Titlebook: Autoimmune Thyroiditis; Approaches Towards i W. A. Scherbaum,U. Bogner,G. F. Bottazzo Conference proceedings 1991 Springer-Verlag Berlin He

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Comparison of New and Conventional Assay Techniques for Measuring Thyroid Microsomal Antibodiest which those antibodies are directed has only recently been identified and appears to be closely related to or identical with thyroid peroxidase (TPO) [2–5]. These advances in defining the microsomal antigen offer a chance to develop new assay techniques for measuring MAb. Hence, new assays rely on

pulmonary

Further Clarification of the Significance of Thyroid Peroxidase Activity-Inhibiting Immunoglobulins xidase (TPO) [1–3], which catalyzes the synthesis of thyroid hormone. We have reported [4] that some anti-TPO antibodies inhibit the activity of TPO in vitro, and that these TPO activity-inhibiting immunoglobulins (TPII) seem to inhibit thyroid function in some patients, but the relationship between

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Biochemical Dissection of the Reactivity of TPO Antibodies, and the microsomal antigens (MAg) is well established. The MAg is a glycoprotein of an apparent molecular weight of about 100kDa [1–3], and its major antigenic component is thyroid peroxidase (TPO) [4–7]. Recently published studies have suggested a heterogeneous nature of autoantibodies directed a

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T Cell Epitopes and Thyroid Peroxidasedes whereas T cells recognize short, lenear amino acid sequences of denatured antigen in association with MHC molecules. Further, detailed analyses of peptides stimulatory for T cells have indicated that such T cell “epitopes” have characteristic patterns of amino acids which may be predicted accord

Coeval

Thyroid Microsome/Thyroid Peroxidase Autoantigenic Epitopes Recognized by Autoantibodies Map to the ase activity [1]. Although their precise role in the aetiology of AITD remains speculative, considerable evidence has accumulated to the effect that aAbs to the thyroid microsome/thyroid peroxidase antigen (TMA/TPO) may be pathogenetic [2]. TPO is a well-characterized enzyme involved in the generati

Culmination

Comparison of Circulating Thyroid Microsomal, Cytotoxic and Thyroid Peroxidase Antibodiesmmune thyroid disease and have been thought to be implicated in thyroid cell damage observed in autoimmune thyroiditis. In support of this concept, antibodies that are cytotoxic for thyroid cells in vitro have been found in the sera of patients with autoimmune thyroiditis and exhibiting antimicrosom

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arthroscopy

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