Titlebook: Atlas of Hepatocellular Carcinoma Pathology; Haeryoung Kim,Wei-Qiang Leow,Anthony Wing-Hung Cha Book 2022 The Editor(s) (if applicable) an

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Stefan Borgwardt,Rafael PeñalozaScirrhous hepatocellular carcinoma (HCC) consists of small oval tumour cells among an extensive fibrotic stroma. Morphological and immunohistochemical features of scirrhous HCC raise a suggestion of stem/progenitor cell-like phenotype.

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Andreas Teucke,Christoph WeidenbachLymphocyte-rich hepatocellular carcinoma (HCC) is a histological subtype of HCC with a diffuse dense intratumoural lymphocytic infiltrate that outnumbers the tumour cells. It is associated with a better prognosis and higher PD-L1 expression.

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Ryota Haga,Yuki Kagaya,Takahito AotoCombined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare tumour that is poorly understood. This chapter aims to clarify the histological morphologies and unravel the use of immunohistochemistry via various pictorial examples.

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KBO Constraint Solving RevisitedThe diagnosis of hepatocellular carcinoma (HCC) is usually straightforward on H&E slides alone. However, ancillary tests are required in some cases to confirm the diagnosis and differentiate among other possibilities. This chapter provides a brief overview on various ancillary tests useful for histological diagnosis of HCC.

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Steatohepatitic Hepatocellular Carcinoma,Steatohepatitic hepatocellular carcinoma (HCC), associated with non-alcoholic fatty liver disease (NAFLD), is a distinct morphological variant of HCC. Although the prognosis is similar to conventional HCCs thus far, there are distinct molecular features. In this chapter, we hope to bring attention to this entity and emphasise potential pitfalls.

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