Titlebook: Assessing Rare Variation in Complex Traits; Design and Analysis Eleftheria Zeggini,Andrew Morris Book 2015 Springer Science+Business Media

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https://doi.org/10.1007/978-1-4939-2824-8complex traits; genetics; genotype; polygenic traits; rare variation

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978-1-4939-4518-4Springer Science+Business Media New York 2015

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Right to Food and “Tragedy” of the CommonsAccurate genotype calling of rare SNPs is an essential prerequisite for genetic studies. In this chapter we provide a systematic approach to derive high-quality SNP calls for this class of variants.

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Rare Variant Quality Control,Accurate genotype calling of rare SNPs is an essential prerequisite for genetic studies. In this chapter we provide a systematic approach to derive high-quality SNP calls for this class of variants.

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Calling Variants from Sequence Data,f variant calling, an introduction to sequence data and the various data formats used to store it, a detailed description of current variant-calling methods and some popular software tools, and a summary.

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Rare Variant Association Analysis: Beyond Collapsing Approaches, may be underpowered in certain scenarios, and approaches that do not directly collapse genotypes of multiple rare variants have been proposed. In this chapter, we describe several non-collapsing approaches, summarize their common and unique features, and discuss their pros and cons.

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y animportant role in complex human phenotypes. This book covers multiple aspects of study design, analysis and interpretation for complex trait studies focusing on rare sequence variation. In many areas of gen978-1-4939-4518-4978-1-4939-2824-8

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Book 2015 many others. There is growing empirical evidence that low-frequency and rare variants play animportant role in complex human phenotypes. This book covers multiple aspects of study design, analysis and interpretation for complex trait studies focusing on rare sequence variation. In many areas of gen

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