| 期刊全称 | Assessing Rare Variation in Complex Traits | | 期刊简称 | Design and Analysis | | 影响因子2023 | Eleftheria Zeggini,Andrew Morris | | 视频video | | | 发行地址 | Covers multiple aspects of study design, analysis and interpretation for complex trait studies focusing on rare sequence variation.Unique in discussing a wide range of design and analysis issues in ge | | 图书封面 |  | | 影响因子 | .This book is unique in covering a wide range of design and analysis issues in genetic studies of rare variants, taking advantage of collaboration of the editors with many experts in the field through large-scale international consortia including the UK10K Project, GO-T2D and T2D-GENES. Chapters provide details of state-of-the-art methodology for rare variant detection and calling, imputation and analysis in samples of unrelated individuals and families. The book also covers analytical issues associated with the study of rare variants, such as the impact of fine-scale population structure, and with combining information on rare variants across studies in a meta-analysis framework..Genetic association studies have in the last few years substantially enhanced our understanding of factors underlying traits of high medical importance, such as body mass index, lipid levels, blood pressure and many others. There is growing empirical evidence that low-frequency and rare variants play animportant role in complex human phenotypes. This book covers multiple aspects of study design, analysis and interpretation for complex trait studies focusing on rare sequence variation. In many areas of gen | | Pindex | Book 2015 |
The information of publication is updating
|
|
发表于 2025-3-21 17:31:13
