Titlebook: Artificial Nucleases; Marina A. Zenkova Book 2004 Springer-Verlag Berlin Heidelberg 2004 Catalysis.Cleavage.Conjugates.DNA.Enzyme mimics.N

exigent

P. L. Melanotte,F. Marconi,E. Tellatin been the object of landmark work in protein chemistry and enzymology (see Cuchillo et al. 1997; Raines 1998 and references therein). In addition, cytotoxic RNase A variants and homologues have demonstrated utility as chemotherapeutic agents (Leland and Raines 2001).

ascend

oxidize

大约冬季

V. Lange,G. Meyer,H. Rau,A. Mewesicial nucleases in either scientific or medical practice. A number of drawbacks hampering a wide application of these oligonucleotide derivatives have been revealed and not yet overcome. One of these drawbacks is insufficient interaction efficiency with a target NA; another, a low selectivity of this interaction.