Titlebook: Artificial Nucleases; Marina A. Zenkova Book 2004 Springer-Verlag Berlin Heidelberg 2004 Catalysis.Cleavage.Conjugates.DNA.Enzyme mimics.N

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dandruff

Günther Schlag,Peter Bösch,Helene Matraser natural ribonucleases such as: higher RNA sequence cleavage specificity, sequence flexibility in designing the site of RNA cleavage, and a wider range of conditions at which artificial ribonucleases are functional (Komiyama et al. 2001).

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Site-Specific Artificial Ribonucleases: Conjugates of Oligonucleotides with Catalytic Groups,998; Sil’nikov and Vlassov 2001). Apart from being useful molecular biology tools (Hüber 1993; Giegé et aL 2000), such compounds may provide new opportunities for design of therapeutics targeting specific messenger RNAs and viral genomic RNAs (Uhlmann and Peymann 1990; Komyiama and Sumaoka 1998; Trawick et aL 1998; Crook et aL 2000).

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https://doi.org/10.1007/978-3-642-18510-6Catalysis; Cleavage; Conjugates; DNA; Enzyme mimics; Nucleotide; RNA; biotechnology; enzymes; biochemical eng

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Y. Moazami-Goudarzi,C. Khodadadyanled as nucleotide units, joined together by phosphate diester links. Given the need to permanently retain genetic information, it is not surprising that the phosphate diester is far more kinetically stable than other common biological functional groups such as amides or esters (Westheimer 1987). How

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