Titlebook: Antisense Therapeutics; M. Ian Phillips Book 2005Latest edition Humana Press 2005 RNA.apoptosis.cancer.cancer therapy.cell.drug.drug deliv

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Antisense Inhibitionh the discovery of RNA interference (RNAi) and development in delivery of these gene drugs, more preclinical and clinical investigations are anticipated to take place in the near future to finally fulfill the promise of antisense therapeutics in humans.

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Springer Series in Solid-State Sciencesf the current lack of a reliable method for early diagnosis, we propose noninvasive measurement of the oncogene expression profile of the cancer and subsequent ablation of those cells expressing the activating oncogenes.

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Radionuclide-Peptide Nucleic Acid in Diagnosis and Treatment of Pancreatic Cancerf the current lack of a reliable method for early diagnosis, we propose noninvasive measurement of the oncogene expression profile of the cancer and subsequent ablation of those cells expressing the activating oncogenes.

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Utility of Antioncogene Ribozymes and Antisense Oligonucleotides in Reversing Drug Resistanceo anticancer drugs: cisplatin, which is exceptionally effective against testicular cancer, ovarian cancer, and others (.); and Ara-C (1-β-.-arabinofuranosyl cytidine, cytosine arabinoside), now a standard for the treatment of acute and chronic leukemia (.).

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Transdermal Delivery of Antisense Oligonucletoidesc systemic levels. The disadvantages of transdermal delivery include limited numbers of potential drug candidates due to their inability to penetrate the skin in sufficient levels, and potential irritation at the application site (.).

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Local Application of Antisense for Prevention of Restenosis.). The artery is injured at the site of PTCA, leading to wound healing responses including thrombosis, smooth muscle proliferation and migration, elastic recoil, and vascular remodeling. Each of these responses may contribute to recurrent obstruction or vessel narrowing, referred to as restenosis.