Titlebook: Antisense Therapeutics; M. Ian Phillips Book 2005Latest edition Humana Press 2005 RNA.apoptosis.cancer.cancer therapy.cell.drug.drug deliv

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Transport of Antisense Across the Blood-Brain Barrier-production of endogenous protein. Administration of antisense therapy could be difficult, however, because peripherally administered antisense would have to cross the blood-brain barrier (BBB) in effective quantities. Several studies have investigated various modifications that can be introduced in

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Transdermal Delivery of Antisense OligonucletoidesThis reduces degradation by the acid and proteolytic enzymes in the gastric environment (.), as well hepatic first-pass elimination (.) and incomplete absorption due to GI motility disorders (.). Transdermal delivery also provides steady-state drug levels and improves patient compliance because of i

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1543-1894 e, brain disorders, the blood-brain barrier, and drug delivery.Highlights include RNA-based therapies for many diseases, up-to-date methods and applications, and insight into the enormous potential to provide a new generation of drugs.978-1-61737-421-0978-1-59259-854-0Series ISSN 1543-1894 Series E-ISSN 1940-6037

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Book 2005Latest editionides are being designed and studied in relation to hypertension, various cancers, inflammatory bowel disease, brain disorders, the blood-brain barrier, and drug delivery.Highlights include RNA-based therapies for many diseases, up-to-date methods and applications, and insight into the enormous poten

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Charge and magnetization densities, and DNA methyltransferase. Clinical studies indicate that AS-ODNs are well tolerated and may have therapeutic activity. In this overview, we summarize therapeutic concepts, clinical studies, and new promising molecular targets to treat human cancer with AS-ODNs.

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Antisense Therapeutics for Hypertensionn reason for patients interrupting their treatment. By not controlling their BP over 24 h, patients experience troughs and peaks in blood pressure (BP). A common regimen of taking a pill in the morning increases the likelihood of stroke or heart attacks at that time, when control is at its weakest.

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