Titlebook: Antisense Therapeutics; M. Ian Phillips Book 2005Latest edition Humana Press 2005 RNA.apoptosis.cancer.cancer therapy.cell.drug.drug deliv

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Antisense Therapeutics for Hypertension of hypertension, the number of patients with controlled hypertension is about 27% in the United States. In all other countries studied, even those such as the United Kingdom and Canada, where cost is not a major factor, patient compliance is even worse. Part of the reason for this problem is that c

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Clinical Studies of Antisense Oligonucleotides for Cancer Therapyhemotherapeutic drugs designed to perturb DNA synthesis or the mitotic event. The development of cytotoxic agents has resulted in improvements in the treatment of leukemia, lymphoma, testicular cancer, and many other solid tumor types (.). Hormone-based drugs have also been useful for breast and pro

巧思

Antisense Therapy in Clinical Oncologyan antisense oligonucleotide (AS-ODN) to the target mRNA makes the antisense strategy attractive for selectively modulating the expression of genes involved in the pathogenesis of malignant or nonmalignant diseases. One antisense drug has been approved for local therapy of cytomegalovirus (CMV) reti

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Radionuclide-Peptide Nucleic Acid in Diagnosis and Treatment of Pancreatic Cancerreas (hereafter simply referred to as pancreatic cancer) occurs more frequently in African-Americans than in European-Americans. The disease progresses rapidly. Pancreatic cancer is usually refractory to treatment, with a median survival time of 12 mo. Overall, only 1% of patients live more than 5 y

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Induction of Tumor Cell Apoptosis and Chemosensitization by Antisense Strategiese use of antisense oligodeoxynucleotides (AS-DONs) directed against gene products overexpressed in tumor cells in synergy with other anticancer agents. In contrast to the low basal levels of the mitogen-dependent cyclin D1 and of the DNA-damage-inducible p53 tumor suppressor protein, tumors with gre