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Titlebook: Antimicrobials; New and Old Molecule Flavia Marinelli,Olga Genilloud Book 2014 Springer-Verlag Berlin Heidelberg 2014 Antibiotics.Bioactive

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发表于 2025-3-21 16:27:50 | 显示全部楼层 |阅读模式
期刊全称Antimicrobials
期刊简称New and Old Molecule
影响因子2023Flavia Marinelli,Olga Genilloud
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发行地址Examines the latest developments in antibacterial research and drug design.Integrates basic and clinical aspects.Written by international experts.Includes supplementary material:
图书封面Titlebook: Antimicrobials; New and Old Molecule Flavia Marinelli,Olga Genilloud Book 2014 Springer-Verlag Berlin Heidelberg 2014 Antibiotics.Bioactive
影响因子.Reports on the emergence and prevalence of resistant bacterial infections in hospitals and communities raise concerns that we may soon no longer be able to rely on antibiotics as a way to control infectious diseases. Effective medical care would require the constant introduction of novel antibiotics to keep up in the “arms race” with resistant pathogens..This book closely examines the latest developments in the field of antibacterial research and development. It starts with an overview of the growing prevalence of resistant Gram-positive and Gram-negative pathogens, including their various resistance mechanisms, prevalence, risk factors and therapeutic options. The focus then shifts to a comprehensive description of all major chemical classes with antibacterial properties, their chemistry, mode of action, and the generation of analogs; information that provides the basis for the design of improved molecules to defeat microbial infections and combat the emerging resistances. In closing, recently developed compounds already in clinical use, those in preclinical or first clinical studies, and a number of promising targets to be exploited in the discovery stage are discussed..
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Novel Infectious Diseases and Emerging Gram-Positive Multi-Resistant Pathogens in Hospital and Commulase-negative staphylococci), enterococci, streptococci, and . are the most important species of clinical interest. Antibiotic resistance issues are common among Gram-positive pathogens, especially among staphylococci and enterococci. Methicillin-resistant . (MRSA) and glycopeptide-resistant enteroc
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Gram-Negative Pathogens: Overview of Novel and Emerging Resistant Pathogens and Drugsthe majority of untreatable bacterial infections. The variety of resistance and transfer mechanisms and their rapid spread among Gram-negative bacteria constitutes a global infection control challenge, and an urgent need for development of new antimicrobials. Unfortunately, infection rates with mult
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Daptomycin and Related Lipopeptides Produced by Fermentation, Chemical Modification, and Combinatoriomycin and related lipopeptides require Ca. for activity, and Ca.-bound daptomycin acts as a cationic peptide and interacts with the negatively charged phosphotidylglycerol (PG) in the cytoplasmic membrane to trigger its antibacterial effects. Mutants of ., ., . and ., which display incremental incr
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Lantibiotics and Similar Peptides Produced by and Active on Gram-Positives: Discovery, Development aforming bridges that confer them characteristic structures. Most lantibiotics are antibacterials that bind to the cell wall precursor lipid II. They can be rod shaped or globular depending on the distribution of the lanthionine residues. Their biosynthetic pathway is relatively simple when compared
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Uridyl Peptide Antibiotics: Developments in Biosynthesis and Medicinal Chemistrydue. Included in this group are the pacidamycins, liposidomycins, capuramycins, and muraymycins. Most of these antibiotics are produced by . species and are naturally found as complexes of closely related congeners. The compounds all bear some resemblance to intermediates involved in cell wall biosy
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