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Titlebook: Antimicrobials; New and Old Molecule Flavia Marinelli,Olga Genilloud Book 2014 Springer-Verlag Berlin Heidelberg 2014 Antibiotics.Bioactive

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Ionic conductance of deep eutectic solvents,ning and in vitro synthesis experiments suggest that there is a great potential for discovery of new lantibiotics. With the increasing need for effective antibiotics against multidrug-resistant pathogens, lantibiotics are an attractive option for a new class of molecules. There are two lantibiotics
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Ionic conductivities of Ch-Cl ,-cresol,as provided evidence for the core features necessary for target inhibition and antibacterial efficacy. Although many of the UPAs have shown potent antibacterial activity, and are effective in inhibiting a highly selective bacterial target, none have progressed to become commercially viable agents. I
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Old and Novel Polymyxins Against Serious Gram-Negative Infectionsbination therapies may be useful, and clinical evidence for their advantages is currently accumulating. Novel, less nephrotoxic compounds that have strong antibacterial activity would be very welcome. The nephrotoxicity of polymyxins might be related to their very highly cationic nature. In contrast
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Uridyl Peptide Antibiotics: Developments in Biosynthesis and Medicinal Chemistryas provided evidence for the core features necessary for target inhibition and antibacterial efficacy. Although many of the UPAs have shown potent antibacterial activity, and are effective in inhibiting a highly selective bacterial target, none have progressed to become commercially viable agents. I
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