Titlebook: Antimalarial Drug II; Current Antimalarial Wallace Peters (Professor of Medical Protozoology) Book 1984 Springer-Verlag Berlin Heidelberg 1

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4-Aminoquinolinesganic chemistry (. and . 1966; . 1967). It was first prepared in 1934 by H. Andersag in the Elberfeld-Leverkusen laboratories of the I. G. Farbenindustrie, as part of a programme which included the synthesis of such important compounds as mepacrine, pentaquine, isopentaquine, pamaquine, primaquine,

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Sulphonamides and Sulphones These are, mainly, the sulphonamides sulfamonomethoxine, sulfadoxine and sulfalene, the sulphone dapsone and, to some extent, also the derivatives of dapsone, diformyldapsone and acedapsone. Only the properties of the single drugs are discussed. (For those of the combinations with pyrimethamine and

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Dihydrofolate Reductase Inhibitorsuanides synthesised as ring-opened analogues possessed good activity against . infections in chicks (. et al. 1945). Later, a group at Burroughs Wellcome who were testing various types of pyrimidines as inhibitors of nucleic acid synthesis pointed out a formal structural analogy between the most act

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Drug Combinationsfor clinical use. The possible value of drug combinations in the prevention of drug resistance will be covered in Chap. 16. Combinations of drugs may be considered under several headings, namely those that are complementary (e.g. against different stages of a parasite), combinations that are additiv

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