Titlebook: Antimalarial Drug II; Current Antimalarial Wallace Peters (Professor of Medical Protozoology) Book 1984 Springer-Verlag Berlin Heidelberg 1

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Exclaim

一再困扰

Dihydrofolate Reductase Inhibitorsowerful, selective inhibition of the activity of malarial dihydrofolate reductase (. et al. 1969). Thus, one compound which was inadvertently synthesised as a prodrug and another which derived from a programme of synthesis of untargeted antimetabolites, together stand as prime examples of chemothera

瘙痒

Lapinone, Menoctone, Hydroxyquinolinequinones and Similar Structures3-(9-hydroxy-9-pentyltetradecyl)1,4-naphthoquinone (II) (lapinone) was synthesised (. et al. 1948a) and shown to be effective in curing patients infected with . (. and . 1951). However, parenteral administration of the drug at fairly high doses was required and this, coupled with the emergence of su

Ataxia

Antibioticsecies, chlortetracycline appeared to be somewhat more active than the other two compounds. The three drugs also exerted a causal prophylactic activity against sporozoite-induced infections of avian malaria. The two tetracyclines and chloramphenicol were the only antibiotics of those tested which wer

TERRA

Book 1984 we asked the contributors to Part 2 of this volume to review very thoroughly the widely scattered but voluminous literature on those few chemical groups that have provided the antimalarial drugs in clinical use at the present time. Much can be learned from the history of their development and the p

Invertebrate

监禁

Luis Baringo,Miguel Carrión,Ruth Domínguez abandoned (in favour of sontoquine) as being “too toxic for human use.” The magnitude of this error of judgement became apparent when, in the course of the American wartime antimalarial survey (. 1946), CQ proved to be the best of the many compounds which were tested for prophylactic-suppressive ac

encomiast

Maedeh Yazdandoust,Masoud Aliakbar Golkarizontocide is more effective or less toxic than primaquine there is a recognised need for investigations to differentiate the efficacy and the toxicity of prima-quine as well as to discover new, less toxic, tissue schizontocides. Thus the Third Meeting of the Scientific Working Group on the Chemothe

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