Titlebook: Anticancer Genes; Stefan Grimm Book 2014 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag Londo

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Induction of Cancer-Specific Cell Death by the Adenovirus E4orf4 Protein expressed alone, outside the context of the virus, E4orf4 induces p53-independent cell-death in transformed cells. Oncogenic transformation of primary cells in tissue culture sensitizes them to cell killing by E4orf4, indicating that E4orf4 research may have implications for cancer therapy. It has

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Tumor Suppressing Properties of Rodent Parvovirus NS1 Proteins and Their Derivativesreatments aiming at several different targets are sought. Viral regulatory proteins, modified or not, appear ideal for this purpose because of their multimodal killing action against neoplastically transformed cells. The large nonstructural protein NS1of rodent parvoviruses is an excellent candidate

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MDA-7/IL-24: Multifunctional Cancer Killing Cytokine-24 has since shown great potential as an anti-cancer gene. MDA-7/IL24, a secreted protein of the IL-10 family, functions as a cytokine at normal physiological levels and is expressed in tissues of the immune system. At supra-physiological levels, MDA-7/IL-24 plays a prominent role in inhibiting tum

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Cancer-Selective Apoptosis by Tumor Suppressor Par-4or suppressor which is unique in its ability to selectively induce apoptosis in cancer cells while leaving the normal cells unaffected. The cancer cell specific activity of Par-4 is elicited through intracellular as well as extracellular mechanisms. Intracellularly Par-4 acts through the inhibition

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