Titlebook: Anticancer Genes; Stefan Grimm Book 2014 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag Londo

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Anticancer Gene Transfer for Cancer Gene Therapy normal cells in addition to the cancer cells. Recently, novel cancer specific viral vectors have been developed that target cancer cells leaving normal cells unharmed. Here we review such cancer specific gene therapy systems currently used in the treatment of cancer and discuss the major challenges and future directions in this field.

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Apoptin Towards Safe and Efficient Anticancer Therapiesxenografted hepatoma and melanoma mouse models PTD4-apoptin protein entered both cancer and normal cells, but only killed cancer cells. Combinatorial treatment of PTD4-apoptin with various (chemo)therapeutic compounds revealed an additive or even synergistic effect, reducing the side effects of the

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Induction of Cancer-Specific Cell Death by the Adenovirus E4orf4 Proteinisms. Although several explanations for the cancer-specificity of E4orf4-induced toxicity have been proposed, a better grasp of the mechanisms responsible for E4orf4-induced cell death is required to elucidate the differential sensitivity of normal and cancer cells to E4orf4.