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Titlebook: Anticancer Genes; Stefan Grimm Book 2014 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag Londo

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,Ausführungslänge der Schnecken,nuclear transfer in cancer cells and efficient cytoplasmic degradation in normal cells. Here, we describe a growing set of preclinical experiments underlying the promises of the anti-cancer potential of apoptin. Various non-replicative oncolytic viral vector systems have revealed the safety and effi
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Bestimmung der Arbeitsprofile der Schnecke,reatments aiming at several different targets are sought. Viral regulatory proteins, modified or not, appear ideal for this purpose because of their multimodal killing action against neoplastically transformed cells. The large nonstructural protein NS1of rodent parvoviruses is an excellent candidate
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Kurven des gleichzeitigen Eingriffes,or suppressor which is unique in its ability to selectively induce apoptosis in cancer cells while leaving the normal cells unaffected. The cancer cell specific activity of Par-4 is elicited through intracellular as well as extracellular mechanisms. Intracellularly Par-4 acts through the inhibition
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Kurven des gleichzeitigen Eingriffes,be instrumental for developing new therapies for cancer. This chapter highlights the rationale for combining biogerontology and cancer research to generate new strategies for cancer treatment. In particular, this chapter focuses on one gene, SIRT6, which has emerged as an important regulator of long
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Kurven des gleichzeitigen Eingriffes,aining attention in the science and medical fields as a rich repository of new pro-drugs. Below, we focus our attention on the Brevinin family of anuran peptides. While most of them show strong antibacterial activities, some, e.g. Brevinin-2R, appear to be promising anticancer molecules, exhibiting
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Kultur und gesellschaftliche Praxisic apoptosis activity. When overexpressed it elicits an apoptosis response in many transformed cells, while normal cells remain unaffected. It can be activated for apoptosis induction by individual tumorigenic mutations in renal cells. This effect is independent of the tumor cells’ proliferation sta
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Lutz Bellmann,Hans-Dieter Gernertems has led to the active development of non-viral techniques. In this chapter, we will discuss two evolving techniques – sonoporation with microbubble contrast agents and electroporation with focus on their basic principle, parameters affecting delivery efficiency, current evolving techniques and
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